The CANTATA-MP Trial (CANagliflozin Treatment and Trial Analysis - Metformin and Pioglitazone)

Completed · Phase 3 · Has a placebo group

Conditions studied: Diabetes Mellitus, Type 2

In brief

The purpose of this study is to evaluate the efficacy and safety of 2 different doses of canagliflozin compared with placebo in patients with type 2 diabetes mellitus who are receving treatment with metformin and pioglitazone and have inadequate glycemic (blood sugar) control.

Key facts

Study ID

NCT01106690

Run by

Janssen Research & Development, LLC

People needed

344

Starts

2010-06-01

Expected to finish

2012-07-01

Last updated by the study team

2013-07-15

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All patients must have a diagnosis of T2DM and be currently treated with PPAR gamma agent ((pioglitazone or rosiglitazone) and another anti-diabetes agent (metformin)
• Patients in the study must have a HbA1c between >=7 and <=10.5% and a fasting plasma glucose (FPG) <270 mg/dL (15 mmol/L)

You may not qualify if…

• History of diabetic ketoacidosis, type 1 diabetes mellitus (T1DM), pancreas or beta cell transplantation, or diabetes secondary to pancreatitis or pancreatectomy
• or a severe hypoglycemic episode within 6 months before screening

Where it is running

• Study site — Phoenix, Arizona, United States
• Study site — Tucson, Arizona, United States
• Study site — Little Rock, Arkansas, United States
• Study site — Burlingame, California, United States
• Study site — Encinitas, California, United States
• Study site — Fullerton, California, United States
• Study site — Roseville, California, United States
• Study site — Santa Ana, California, United States
• Study site — Wes Hills, California, United States
• Study site — Colorado Springs, Colorado, United States
• Study site — Bartow, Florida, United States
• Study site — Hollywood, Florida, United States
• Study site — Jacksonville, Florida, United States
• Study site — Pembroke Pines, Florida, United States
• Study site — Des Moines, Iowa, United States
• Study site — Baton Rouge, Louisiana, United States
• Study site — Chaska, Minnesota, United States
• Study site — Picayune, Mississippi, United States
• Study site — Billings, Montana, United States
• Study site — Charlotte, North Carolina, United States
• Study site — Hickory, North Carolina, United States
• Study site — Raleigh, North Carolina, United States
• Study site — Dublin, Ohio, United States
• Study site — Perrysburg, Ohio, United States
• Study site — Anniston, Alabama, United States

Full record on ClinicalTrials.gov

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