The CANTATA-D Trial (CANagliflozin Treatment and Trial Analysis - DPP-4 Inhibitor Comparator Trial)

Completed · Phase 3 · Has a placebo group

Conditions studied: Diabetes Mellitus, Type 2

In brief

The purpose of this study is to evaluate the efficacy and safety of canagliflozin compared with sitagliptin and placebo in patients with type 2 diabetes mellitus who are receiving treatment with metformin monotherapy (i.e., treatment with a single drug) and have inadequate glycemic (blood sugar) control.

Key facts

Study ID

NCT01106677

Run by

Janssen Research & Development, LLC

People needed

1284

Starts

2010-05-01

Expected to finish

2012-05-01

Last updated by the study team

2013-07-30

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All patients must have a diagnosis of T2DM and be currently treated with metformin IR
• Patients in the study must have a HbA1c between >=7 and <=10.5%
• Patients must have a fasting plasma glucose (FPG) <270 mg/dL (15 mmol/L)

You may not qualify if…

• History of diabetic ketoacidosis, type 1 diabetes mellitus (T1DM), pancreas or beta cell transplantation, diabetes secondary to pancreatitis or pancreatectomy, or a severe hypoglycemic episode within 6 months before screening

Where it is running

• Study site — Fountain Valley, California, United States
• Study site — National City, California, United States
• Study site — Northridge, California, United States
• Study site — Colorado Springs, Colorado, United States
• Study site — Denver, Colorado, United States
• Study site — Bradenton, Florida, United States
• Study site — Brooksville, Florida, United States
• Study site — DeFuniak Springs, Florida, United States
• Study site — Hialeah, Florida, United States
• Study site — Niceville, Florida, United States
• Study site — Tampa, Florida, United States
• Study site — Atlanta, Georgia, United States
• Study site — Savannah, Georgia, United States
• Study site — Champaign, Illinois, United States
• Study site — Avon, Indiana, United States
• Study site — Fishers, Indiana, United States
• Study site — Franklin, Indiana, United States
• Study site — West Des Moines, Iowa, United States
• Study site — Wichita, Kansas, United States
• Study site — Munfordville, Kentucky, United States
• Study site — Portland, Maine, United States
• Study site — Benzonia, Michigan, United States
• Study site — Interlochen, Michigan, United States
• Study site — Troy, Michigan, United States
• Study site — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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