Neutrophil Extracellular Trap Formation in Newborn Infants at Risk for Inflammatory Syndromes
Stopped early
Conditions studied: Prematurity, Necrotizing Enterocolitis
In brief
The purpose of this study is to characterize the time to maturation of neutrophil extracellular trap(NET) formation capability in polymorphonuclear leukocytes(PMNs) isolated from newborn premature and term infants. Preterm infants who are enrolled into the study who then go on to require surgery \<1 year due to surgical NEC, will have the NET formation reassessed. This study will also determine whether NETs contribute to the pathogenesis of necrotizing enterocolitis (NEC). We hypothesize that NET formation contributes to the pathogenesis of NEC by inappropriately releasing degradative proteins and tissue destructive enzymes into the inflammatory milieu of the premature infant gastrointestinal tract following bacterial translocation. We also hypothesize that the delay in NEC development in premature infants (3rd - 4th week of life) as compared to at-risk term infants (1st week of life) results from a developmental delay in PMN ability to form NETs.
Key facts
- Study ID
- NCT01106209
- Run by
- University of Utah
- People needed
- 14
- Starts
- 2010-04-01
- Expected to finish
- 2020-06-22
- Last updated by the study team
- 2025-03-18
Who can join
Age: any, up to 1. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Preterm infant patients delivered at UUMC and hospitalized in the NICU who are ≤ 1500 grams or <30 weeks gestational age at birth
- Term infants delivered at UUMC without complication, either via cesarean section or vaginal delivery
You may not qualify if…
- No other exclusion criteria
Where it is running
- University of Utah — Salt Lake City, Utah, United States
- Primary Children's Medical Center — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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