Panobinostat and Letrozole in Treating Patients With Metastatic Breast Cancer
Completed · Phase 1/Phase 2
Conditions studied: Breast Cancer
In brief
RATIONALE: Panobinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Estrogen can cause the growth of breast cancer cells. Hormone therapy using letrozole may fight breast cancer by lowering the amount of estrogen the body makes. Giving panobinostat together with letrozole may be an effective treatment for breast cancer. PURPOSE: This phase I/II trial is studying the side effects and best dose of panobinostat when given together with letrozole and to see how well it works in treating patients with metastatic breast cancer.
Key facts
- Study ID
- NCT01105312
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 28
- Starts
- 2010-09-01
- Expected to finish
- 2013-09-03
- Last updated by the study team
- 2017-06-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Contra Costa Regional Medical Center — Martinez, California, United States
- El Camino Hospital Cancer Center — Mountain View, California, United States
- Bay Area Breast Surgeons, Incorporated — Oakland, California, United States
- CCOP - Bay Area Tumor Institute — Oakland, California, United States
- Larry G Strieff MD Medical Corporation — Oakland, California, United States
- Tom K Lee, Incorporated — Oakland, California, United States
- Study site — Pismo Beach, California, United States
- Doctors Medical Center - San Pablo Campus — San Pablo, California, United States
- Aurora Presbyterian Hospital — Aurora, Colorado, United States
- Boulder Community Hospital — Boulder, Colorado, United States
- Penrose Cancer Center at Penrose Hospital — Colorado Springs, Colorado, United States
- St. Anthony Central Hospital — Denver, Colorado, United States
- Porter Adventist Hospital — Denver, Colorado, United States
- Presbyterian - St. Luke's Medical Center — Denver, Colorado, United States
- St. Joseph Hospital — Denver, Colorado, United States
- Rose Medical Center — Denver, Colorado, United States
- Swedish Medical Center — Englewood, Colorado, United States
- Poudre Valley Hospital — Fort Collins, Colorado, United States
- Front Range Cancer Specialists — Fort Collins, Colorado, United States
- North Colorado Medical Center — Greeley, Colorado, United States
- Sky Ridge Medical Center — Lone Tree, Colorado, United States
- Hope Cancer Care Center at Longmont United Hospital — Longmont, Colorado, United States
- McKee Medical Center — Loveland, Colorado, United States
- St. Mary - Corwin Regional Medical Center — Pueblo, Colorado, United States
- Mayo Clinic Scottsdale — Scottsdale, Arizona, United States
Full record on ClinicalTrials.gov
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