Study of Oral ENMD-2076 Administered to Patients With Ovarian Cancer

Completed · Phase 2

Conditions studied: Ovarian Cancer, Fallopian Cancer, Peritoneal Cancer

In brief

The purpose of this study is to determine whether oral ENMD-2076 is effective in treatment of patients with platinum resistant ovarian, fallopian, or peritoneal cancer. Additional sites to be added.

Key facts

Study ID

NCT01104675

Run by

CASI pharmaceuticals, Inc.

People needed

64

Starts

2010-04-01

Expected to finish

2012-12-01

Last updated by the study team

2014-08-06

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Have histologically documented diagnosis of ovarian, fallopian or peritoneal cancer that is platinum resistant.
• Have a pre-study echocardiogram or multigated acquisition (MUGA) scan with an actual left ventricular ejection fraction of greater than or equal to the institution lower limit of normal
• Greater than or equal to 18 years of age
• Have clinically acceptable laboratory screening results
• Have an ECOG performance status of 0 or 1
• Able to tolerate oral medications

You may not qualify if…

• Have uncontrolled hypertension (systolic blood pressure greater than 150mmHg or diastolic blood pressure greater than 100mmHg); require two or more antihypertensive medications to control hypertension (including ACE inhibitors, beta blockers, calcium channel blockers, or diuretics)
• Have chronic atrial fibrillation or QTc interval corrected for heart rate of greater than 470 msec
• Have active, acute, or chronic clinically significant infections or bleeding
• Have persistent 2+ protein by urinalysis or a history of nephrotic syndrome

Where it is running

• University of Colorado Cancer Center — Aurora, Colorado, United States
• University of Chicago Medical Center — Chicago, Illinois, United States
• Indiana University Simon Cancer Center — Indianapolis, Indiana, United States
• Dana Farber/Partners Cancer Care — Boston, Massachusetts, United States
• Memorial Sloan-Kettering Cancer Center — New York, New York, United States
• Princess Margaret Hospital — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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