Exercise to Improve Outcomes of Treatment for Methamphetamine Users

Completed · Not applicable

Conditions studied: Addiction

In brief

The purpose of this study is to assess the effects of an aerobic and strength training exercise program (one that increases the need for oxygen and increases muscle) on the treatment outcomes of 150 individuals in treatment for methamphetamine dependence at Cri-Help. The study will determine if a 60-minute exercise program (three times a week) has an effect (good or bad) on the health and drug use of participants as compared to individuals not participating in an exercise program.

Key facts

Study ID

NCT01103531

Run by

University of California, Los Angeles

People needed

135

Starts

2010-03-01

Expected to finish

2015-07-01

Last updated by the study team

2015-12-02

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Be seeking treatment for their MA dependence;
• Be 18 years of age or older, and 45 or younger for males, 55 or younger for females;
• Meet DSM-IV-TR criteria for MA dependence;
• Have vital signs that are within clinically acceptable normal range, e.g., resting pulse between 50 and 90 /min, blood pressures between 85-150mm Hg systolic and 45-90mm Hg diastolic;
• Have a medical history and physical examination that, in the judgment of the study physician or Principal Investigator, show no clinically significant contraindications for study participation;
• For females, provide negative pregnancy urine tests before randomization (and for the sub-sample, another negative test before the final PET scan at the conclusion of the intervention).

You may not qualify if…

• Clinically significant heart disease or hypertension; unstable pulmonary or cardiovascular disease that would interfere with participation in exercise regimen
• Neurological or psychiatric disorders as assessed by MINI or clinical interview, such as psychosis, bipolar illness, Tourette's syndrome, major depression, organic brain disease, dementia, or any other neuro-psychiatric disorder that would require ongoing treatment or that would make study compliance difficult;
• Musculoskeletal disease that would prevent participation in exercise regimen
• Baseline ECG showing evidence of cardiac ischemia, arrhythmia, or other clinically significant abnormalities
• Untreated or unstable medical illness including: neuroendocrine, autoimmune, renal, hepatic, or active infectious disease (other than HIV) that requires immediate medical attention;
• Clinically significant abnormalities in hematology and chemistry laboratory tests that may make participation hazardous;
• Have HIV and unable to obtain a clearance for participation from his/her AIDS medical care provider;
• Pregnant;
• Any other illness, condition, or use of medications that, in the opinion of the PI and/or the study physician, would preclude safe participation or completion of the study.

Where it is running

• Cri-Help, Inc — North Hollywood, California, United States

Full record on ClinicalTrials.gov

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