Aldosterone and the Metabolic Syndrome

Completed · Phase 1

Conditions studied: Metabolic Diseases, Diabetes Mellitus, Endocrine System Diseases, Glucose Metabolism Disorders

In brief

The purpose of this study is to determine the effects of mineralocorticoid receptor (MR) antagonism and renin inhibition on glucose metabolism in humans.

Key facts

Study ID

NCT01103245

Run by

Vanderbilt University Medical Center

People needed

69

Starts

2010-03-01

Expected to finish

2013-09-01

Last updated by the study team

2018-11-05

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects meeting all of the following conditions will be included in the study:
• Ambulatory subjects, 18 to 70 years of age, inclusive
• For female subjects, the following conditions must be met:
• postmenopausal status for at least 1 year, or
• status-post surgical sterilization, or
• if of childbearing potential, utilization of adequate birth control and willingness to undergo urine beta-hcg testing prior to drug treatment and on every study day.
• A seated or supine systolic blood pressure greater than 130/85 on three separate measurements at least 15 minutes apart
• Metabolic Syndrome as defined by the presence of > 3 of the following:
• Hypertension as characterized by having Systolic Blood Pressure > 140 mm Hg and Diastolic Blood Pressure > 90 mm Hg.
• Impaired Glucose Tolerance (Fasting Plasma Glucose > 100 mg/dL)
• Increased triglyceride level > 150mg/dL
• Decreased levels of High-Density Lipoprotein (HDL) cholesterol
• For males, less than 30 mg/dL
• For females, less than 40 mg/dL
• Waist circumference
• For males, greater than 40 inches.
• For females, greater than 35 inches.

You may not qualify if…

• Subjects presenting with any of the following will not be included in the study:
• Diabetes type 1 or type 2, a fasting glucose of greater than 110 mg/dL or the use of anti-diabetic medication
• Use of hormone replacement therapy
• Statin therapy
• Pregnancy
• Breast-feeding
• Cardiovascular disease such as prior myocardial infarction, presence of angina pectoris, significant arrhythmia, congestive heart failure [Left Ventricular (LV) hypertrophy acceptable], deep vein thrombosis, pulmonary embolism, second or third degree heart block, mitral valve stenosis, aortic stenosis or hypertrophic cardiomyopathy
• Treatment with anticoagulants
• History of serious neurologic disease such as cerebral hemorrhage, stroke, seizure, or transient ischemic attack
• History or presence of immunological or hematological disorders
• Diagnosis of asthma requiring use of inhaled beta agonist >1 time per week
• Clinically significant gastrointestinal impairment that could interfere with drug absorption
• Impaired hepatic function [aspartate amino transaminase (AST) and/or alanine amino transaminase (ALT) >1.5 x upper limit of normal range]
• Impaired renal function [estimated glomerular filtration rate (eGFR) of <60ml/min] as determined by the four-variable Modification of Diet in Renal Disease (MDRD) equation, where serum creatinine (Scr) is expressed in mg/dl and age in years:
• eGFR (ml/min/1.73m2)=175 • Scr-1.154 • age-0.203 • (1.212 if black) • (0.742 if female)
• Hematocrit <35%
• Any underlying or acute disease requiring regular medication which could possibly pose a threat to the subject or make implementation of the protocol or interpretation of the study results difficult, such as arthritis treated with non-steroidal antiinflammatory drugs
• Treatment with chronic systemic glucocorticoid therapy (more than 7 consecutive days in 1 month)
• Treatment with lithium salts
• History of alcohol or drug abuse
• Treatment with any investigational drug in the 1 month preceding the study
• Mental conditions rendering the subject unable to understand the nature, scope and possible consequences of the study
• Inability to comply with the protocol, e.g., uncooperative attitude, inability to return for follow-up visits, and unlikelihood of completing the study
• Screening plasma potassium <3.2 mmol/L or use of chronic potassium supplements for the treatment of hypokalemia

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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