Validation of a Mouse Model of Pancreatic Carcinogenesis
Stopped early
Conditions studied: Pancreatic Cancer
In brief
The primary aim of this study is to determine if mutations of BRCA1 and BRCA2 result in different precancerous pathways to pancreatic ductal adenocarcinoma (PDAC), as suggested in our validated mouse model. Genomic DNA will be isolated on normal tissue obtained from patients who underwent pancreatic resection for PDAC, intraductal papillary mucinous neoplasm (IPMN) or mucinous cystic neoplasm (MCN). Tissue will be examined for the three most common founder mutations in Ashkenazi Jews. In the cases in which BRCA1 or BRCA2 mutations are found, heterozygote normal and abnormal tissue will be examined to look for mutations in the other BRCA1 or BRCA2 allele. The interaction between other cancer causing genes with BRCA1/2 will also be evaluated by comparing the sequences of the other genes in pre-cancerous lesions. We hypothesize that BRCA1- and BRCA2-mediated pancreatic ductal adenocarcinoma progresses through the PanIN route, as seen in both BRCA1 and BRCA2 murine models of pancreatic cancer. We further hypothesize that BRCA1 mutations may enable an additional pre- neoplastic pathway through MCN, and that IPMN may embody yet another pre- neoplastic pathway.
Key facts
- Study ID
- NCT01103128
- Run by
- Columbia University
- People needed
- 450
- Starts
- 2009-03-01
- Expected to finish
- 2013-05-01
- Last updated by the study team
- 2015-06-23
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Tissue-confirmed diagnosis of pancreatic adenocarcinoma, MCN, or IPMN.
- Underwent surgical resection for pancreatic adenocarcinoma, MCN, or IPMN.
You may not qualify if…
- Unwilling to provide informed consent.
- Under the age of 18.
Where it is running
- Columbia University Medical Center — New York, New York, United States
Full record on ClinicalTrials.gov
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