Clinical Trial to Examine the Pain Relief of PH-797804 Alone Or With Naproxen in Subjects With Osteoarthritis of the Knee

Completed · Phase 2 · Has a placebo group

Conditions studied: Osteoarthritis

In brief

PH-797804 is a potent inhibitor of inflammatory mediators that have a potential role in pain signalling following nerve injury and inflammation. Blocking such mediators may potentially have a therapeutic benefit by reducing pain.

Key facts

Study ID

NCT01102660

Run by

Pfizer

People needed

172

Starts

2010-05-01

Expected to finish

2011-03-01

Last updated by the study team

2014-08-22

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female subjects between, and including, the ages of 18 and 75 years. Females must be of non-childbearing potential.
• Diagnosis of osteoarthritis of the knee based on American College of Rheumatology criteria with X-ray confirmation (a Kellgren-Lawrence X-ray grade of ≥2.

You may not qualify if…

• History of diseases other than osteoarthritis that may involve the index knee.
• Other severe pain that impairs the assessment of osteoarthritis of pain.
• Electrocardiogram abnormalities.
• History of gastrointestinal disorders.

Where it is running

• Pfizer Investigational Site — Paramount, California, United States
• Pfizer Investigational Site — Spring Valley, California, United States
• Pfizer Investigational Site — Valley Village, California, United States
• Pfizer Investigational Site — Daytona Beach, Florida, United States
• Pfizer Investigational Site — Ormond Beach, Florida, United States
• Pfizer Investigational Site — Plantation, Florida, United States
• Pfizer Investigational Site — Plantation, Florida, United States
• Pfizer Investigational Site — South Miami, Florida, United States
• Pfizer Investigational Site — Gurnee, Illinois, United States
• Pfizer Investigational Site — Overland Park, Kansas, United States
• Pfizer Investigational Site — Overland Park, Kansas, United States
• Pfizer Investigational Site — Overland Park, Kansas, United States
• Pfizer Investigational Site — Prairie Village, Kansas, United States
• Pfizer Investigational Site — Wichita, Kansas, United States
• Pfizer Investigational Site — Fall River, Massachusetts, United States
• Pfizer Investigational Site — Hyannis, Massachusetts, United States
• Pfizer Investigational Site — New Bedford, Massachusetts, United States
• Pfizer Investigational Site — St Louis, Missouri, United States
• Pfizer Investigational Site — Rochester, New York, United States
• Pfizer Investigational Site — Wilmington, North Carolina, United States
• Pfizer Investigational Site — Kettering, Ohio, United States
• Pfizer Investigational Site — Pawtucket, Rhode Island, United States
• Pfizer Investigational Site — Mt. Pleasant, South Carolina, United States
• Pfizer Investigational Site — New Tazewell, Tennessee, United States
• Pfizer Investigational Site — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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