Prandial Insulin Dosing in Hospitalized Patients
Completed · Phase 4
Conditions studied: Diabetes, Admitting Hospital, Non-critically Ill
In brief
The purpose of this study is to determine whether mealtime insulin results in better control of blood sugar than a fixed meal dose in hospitalized patients.
Key facts
- Study ID
- NCT01101867
- Run by
- Kathleen Dungan
- People needed
- 126
- Starts
- 2010-06-01
- Expected to finish
- 2013-03-01
- Last updated by the study team
- 2018-01-31
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- general medical or minor surgical hospitalized patients
- type 2 diabetes
- blood glucose 150-400 on at least 2 occasions within 24 hours or requiring at least 20 units of insulin/day in the 24 hours prior to enrollment
You may not qualify if…
- • Major surgery, occurring within the previous 2 weeks or planned within 72 hours of study entry, including cardiothoracic, neurosurgical, and open intra-abdominal procedures (in particular, any surgery lasting over 2 hours).
- Patients receiving glucocorticoids, total parental nutrition (TPN), or tube feeds.
- Pregnancy (glucose targets differ in pregnancy). Premenopausal women not on pharmacologic contraceptives, inrauterine device (IUD), or surgical menopause will undergo pregnancy testing.
- Patients currently on IV insulin (must wait to enroll) or with planned surgical procedures in the next 72 hours for whom intravenous insulin will be likely
- Prolonged (>24 hour) strict nil per os (NPO-nothing by mouth) status (eg. small bowl obstruction). Liquid or modified consistency diets are acceptable.
- Patients for whom expected length of stay will be less than 48 hours
- Patients using subcutaneous insulin pumps
- Diabetic ketoacidosis
- End-stage renal disease on dialysis
- End-stage liver disease with cirrhosis
- Mental conditions precluding informed consent
- Potentially sensitive admissions: prisoners, HIV, suicidality
- Unable to give consent in English
Where it is running
- The Ohio State University — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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