A Phase III Randomized Trial of Metformin vs Placebo in Early Stage Breast Cancer

Completed · Phase 3 · Has a placebo group

Conditions studied: Breast Cancer

In brief

This study is looking at whether Metformin, an agent that is commonly used to treat diabetes, can decrease or affect the ability of breast cancer cells to grow and whether Metformin will work with other therapies to keep cancer from recurring. Health Canada has not approved the sale or use of Metformin to treat breast cancer, although they have approved its use in this clinical trial. Although Metformin is approved by the FDA for the treatment of diabetes, its use in breast cancer is considered investigational.

Key facts

Study ID

NCT01101438

Run by

Canadian Cancer Trials Group

People needed

3649

Starts

2010-08-13

Expected to finish

2023-08-18

Last updated by the study team

2023-09-13

Who can join

Age: 18 and older, up to 74. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Fairbanks Memorial Hospital — Fairbanks, Alaska, United States
• Pinnacle Oncology Associates — Scottsdale, Arizona, United States
• Mayo Clinic in Arizona — Scottsdale, Arizona, United States
• Arizona Cancer Center at University Medical Center North — Tucson, Arizona, United States
• University of Arizona Health Sciences Center — Tucson, Arizona, United States
• Kaiser Permanente-Deer Valley Medical Center — Antioch, California, United States
• Alta Bates Summit Medical Center-Herrick Campus — Berkeley, California, United States
• Enloe Medical Center — Chico, California, United States
• Glendale Memorial Hospital and Health Center — Glendale, California, United States
• Kaiser Permanente, Hayward — Hayward, California, United States
• Moores University of California San Diego Cancer Center — La Jolla, California, United States
• Long Beach Memorial Medical Center-Todd Cancer Institute — Long Beach, California, United States
• University of Southern California — Los Angeles, California, United States
• University of California at Los Angeles (UCLA ) — Los Angeles, California, United States
• Fremont - Rideout Cancer Center — Marysville, California, United States
• Bay Area Tumor Institution CCOP — Oakland, California, United States
• Kaiser Permanente-Oakland — Oakland, California, United States
• University of California Medical Center At Irvine-Orange Campus — Orange, California, United States
• Pomona Valley Hospital Medical Center — Pomona, California, United States
• Kaiser Permanente-Redwood City — Redwood City, California, United States
• Kaiser Permanente-Richmond — Richmond, California, United States
• Kaiser Permanente-Roseville — Roseville, California, United States
• University of California Davis-Cancer Center — Sacramento, California, United States
• Kaiser Permanente-South Sacramento — Sacramento, California, United States
• Providence Alaska Medical Center — Anchorage, Alaska, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.