Effects of Almonds on Cardiovascular Risk Factors

Completed · Not applicable

Conditions studied: Cardiovascular Disease

In brief

The purpose of this research is to build the evidence base for approval of FDA health claims related to almonds and cardiovascular disease. A randomized, 2-period, crossover controlled feeding study was designed to compare the effects of two blood cholesterol lowering diets that meet the American Heart Association recommendations. The nutrient profiles of the control diet (no almonds/day) and almond diet (1.5 oz. of almonds/day) are matched for protein, saturated fat, and cholesterol. The study population consists of two cohorts of 25 men and women with moderately elevated LDL-C. The investigators hypothesize that a cholesterol-lowering diet designed with almonds confers greater cardioprotective effects than a cholesterol-lowering diet without almonds on the basis of the LDL-C lowering response, effect on LDL particle size, abdominal adiposity and vascular health.

Key facts

Study ID

NCT01101230

Run by

Penn State University

People needed

61

Starts

2009-09-01

Expected to finish

2012-05-01

Last updated by the study team

2023-08-21

Who can join

Age: 30 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• BMI (20-35)
• Low density lipoprotein cholesterol males (128-194mg/dL) and females (121-190 mg/dL)

You may not qualify if…

• Pregnant, planning to become pregnant, or lactating
• Smoking; cholesterol-lowering medication
• Glucose-lowering medication
• Over the counter cholesterol-lowering substances (e.g.: psyllium, fish oil, soy lecithin, phytoestrogen)
• The following medical conditions:
• heart disease
• stroke
• Heart attack
• blood pressure >140/90
• diabetes
• renal or kidney disease
• rheumatoid arthritis
• blood clotting disorder
• liver disease or cirrhosis
• compromised immune system
• peripheral vascular disease or circulation problems
• > 10% body weight loss in the past 6 months
• vegetarian
• nut allergies

Where it is running

• Penn State University — University Park, Pennsylvania, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.