Effect Of Biomechanical Stimulation On Skeletal Health In Adolescent And Young Women With Anorexia Nervosa

Completed · Not applicable · Has a placebo group

Conditions studied: Anorexia Nervosa

In brief

This study will evaluate the effects of a novel, non-pharmacologic intervention for the prevention of deleterious changes in bone density and strength in adolescents with anorexia nervosa (AN), a disease commonly treated with extended periods of bed rest and immobilization. The primary focus of the trial is to conduct a prospective short-term intervention to prevent an uncoupling of bone turnover in inpatients hospitalized for AN, and to determine the long-term effects of a biomechanical intervention on skeletal health in ambulatory adolescents with AN.

Key facts

Study ID

NCT01100567

Run by

Boston Children's Hospital

People needed

101

Starts

2009-04-01

Expected to finish

2015-05-01

Last updated by the study team

2017-05-17

Who can join

Age: 11 and older, up to 25. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age 11-25 years
• Diagnosis of anorexia nervosa based on DSM-IV criteria
• Female gender
• English-speaking

You may not qualify if…

• • Concomitant chronic diseases which affect bone health, such as cystic fibrosis, inflammatory bowel disease, celiac disease, renal disease, or diabetes mellitus
• Use of medications known to affect bone metabolism in the last 3 months, such as:
• Glucocorticoid therapy (including inhaled steroids)
• Anticonvulsants
• Combined estrogen/progestin contraceptive agents (oral contraceptive pills)
• Depot medroxyprogesterone (Depo-Provera) use in the last 12 months
• Current pregnancy

Where it is running

• Children's Hospital Boston — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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