Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy

Completed · Phase 3 · Has a placebo group

Conditions studied: Chemotherapeutic Agent Toxicity, Colorectal Cancer, Neuropathy, Neurotoxicity

In brief

RATIONALE: Chemoprotective drugs, such as calcium gluconate and magnesium sulfate, may prevent neurotoxicity caused by oxaliplatin. It is not yet known which administration schedule of calcium gluconate and magnesium sulfate is more effective in preventing neurotoxicity. PURPOSE: This randomized phase III trial is studying different administration schedules of calcium gluconate and magnesium sulfate and comparing how well they work in neurotoxicity in patients with colon cancer or rectal cancer receiving oxaliplatin-based combination chemotherapy.

Key facts

Study ID
NCT01099449
Run by
Alliance for Clinical Trials in Oncology
People needed
362
Starts
2010-06-01
Expected to finish
2013-03-01
Last updated by the study team
2022-11-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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