Apoptotic Cell (AC) Uptake by Human Alveolar Macrophages (AM)

Completed

Conditions studied: Chronic Obstructive Pulmonary Disease

In brief

The purpose of this study is to compare the ability of two types of white blood cells to eat dead host cells, and how this process affects their ability to protect the body from infection. The two cell types are monocytes, a cell in the bloodstream, and alveolar macrophages, a cell in the lung that is ultimately derived from monocytes

Key facts

Study ID

NCT01099410

Run by

VA Office of Research and Development

People needed

17

Starts

2010-02-01

Expected to finish

2015-12-01

Last updated by the study team

2016-01-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Veteran or non-Veteran
• Able to give informed consent

You may not qualify if…

• Unstable heart disease
• Other systemic disease and unlikely to survive at least 2 years
• Mental incompetence
• Prednisone >20 mg/day
• Participation in another interventional protocol within last 6 weeks
• Asthma
• Cystic fibrosis
• Clinically significant bronchiectasis
• Lung cancer or any cancer not in remission for at least 5 years
• Other inflammatory or fibrotic lung disease
• Use of antibiotics for a lung infection within the past 4 weeks
• Autoimmune disease, i.e., Rheumatoid arthritis, systemic lupus erythematosus, autoimmune hepatitis, Crohn's disease or other

Where it is running

• VA Ann Arbor Healthcare System, Ann Arbor, MI — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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