Combination Targeted Radiotherapy in Neuroendocrine Tumors
Completed · Not applicable
Conditions studied: Neuroendocrine Tumors
In brief
The primary aim of this project is to determine, what fraction of individuals with neuroendocrine tumors would show substantially improved tumor dosimetry with combined agent therapy compared to "best" single agent therapy and determine the magnitude of the potential tumor radiation dose increase.
Key facts
- Study ID
- NCT01099228
- Run by
- David Bushnell
- People needed
- 2
- Starts
- 2006-09-01
- Expected to finish
- 2015-07-01
- Last updated by the study team
- 2016-07-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects with biopsy-proven metastatic (soft tissue) neuroendocrine tumors.
- Subjects with a Southwest Oncology Group (SWOG) performance score of 0-2 and an expected median survival of at least 6 months.
- The subject is able and willing to comply with study procedures and a signed and dated informed consent is obtained.
- Subjects must be >18 years of age
You may not qualify if…
- Subjects who use medications that are known to interfere with MIBG uptake and is unable to discontinue for medical reasons.
- Prior chemotherapy, radiotherapy or any investigational drugs within 60 days prior admission into this study. Patients must have recovered from all therapy-related toxicities
- Renal insufficiency with a serum creatinine 2 X ULN
- Subjects unable to lie still for the imaging studies.
- Subjects who because of their weight and body distribution do not fit into the imaging machine.
- Subjects receiving Sandostatin LAR < 21 days prior to dosing or Sandostatin Immediate Release (IR) < 24 hours prior to dosing.
- Female patients who are pregnant or breast feeding. Women of childbearing potential must have a negative serum/urine pregnancy test within 48 hours prior to administration of study treatment.
Where it is running
- University of Iowa — Iowa City, Iowa, United States
- Department of Veteran Affairs Medical Center — Iowa City, Iowa, United States
Full record on ClinicalTrials.gov
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