The Biologic Basis of Hernia Formation

Completed

Conditions studied: Hiatal Hernia, Paraesophageal Hernia

In brief

The study will examine potential biological and genetic mechanisms leading to hiatal and paraesophageal hernia formation in predisposed individuals. It is expected that these patients will have defects in the normal production and maturation of collagen and other connective tissue proteins, thus leading to weakness in the diaphragm that may allow for spontaneous herniation. Comparison of tissue and blood samples from these patients (study group) will be made to those from individuals undergoing lower esophageal surgery who have not developed a concurrent hernia (i.e. esophageal myotomy for achalasia and laparoscopic gastric bypass or laparoscopic adjustable gastric banding for morbid obesity - control group).

Key facts

Study ID

NCT01099033

Run by

Washington University School of Medicine

People needed

151

Starts

2007-08-01

Expected to finish

2011-10-01

Last updated by the study team

2018-05-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Any patient undergoing paraesophageal hernia repair, esophageal myotomy, laparoscopic gastric bypass, or laparoscopic adjustable gastric banding.

You may not qualify if…

• Pregnant females, minors, prisoners

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.