Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia

Status unconfirmed

Conditions studied: Congenital Diaphragmatic Hernia

In brief

Congenital diaphragmatic hernia (CDH) occurs when the diaphragm, the muscle that separates the chest cavity from the abdominal cavity, does not form properly. When an opening is present in the diaphragm, organs that are normally found in the abdomen can move up into the chest cavity. The primary objective of this study is to generate information about the hereditary basis of congenital diaphragmatic hernia and abnormal lung development. Our long-term goal is to identify ways to treat babies in utero with effective but safe drugs to speed up lung development before birth.

Key facts

Study ID

NCT01098929

Run by

Massachusetts General Hospital

People needed

1000

Starts

2002-07-01

Expected to finish

2017-07-01

Last updated by the study team

2015-12-17

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All individuals affected with a congenital diaphragmatic hernia (CDH), or with a family history of CDH

You may not qualify if…

• Individuals with no personal or family history of a CDH

Where it is running

• Children's Hospital Boston — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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