HIV Fat Redistribution and the Evaluation of Brown Fat

Completed

Conditions studied: HIV Infections

In brief

The specific aims of this study are to determine whether HIV-infected patients with significant fat redistribution and ectopic fat accumulation have increased brown adipose tissue using 18F-FDG Positron Emission Tomography techniques. Recent studies suggest down regulation of Dicer, a major component of miRNA has an important role in the differentiation and function of brown and white adipose tissue and may contribute to lipodystrophy. Therefore we will expand on recent research in this area by recruiting HIV-infected men with lipodystrophy. We will perform subcutaneous fat biopsies of the dorsocervical and abdominal fat in a subset of HIV-infected and non-HIV-infected men in order to explore further the question of down regulation of Dicer and its implication on metabolic abnormalities in this population.

Key facts

Study ID
NCT01098045
Run by
Massachusetts General Hospital
People needed
27
Starts
2010-03-01
Expected to finish
2015-08-01
Last updated by the study team
2021-08-16

Who can join

Age: 20 and older, up to 60. Sex: male. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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