A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery

Completed · Not applicable · Has a placebo group

Conditions studied: Postoperative Pain

In brief

The purpose of this study is to compare the efficacy of pregabalin to placebo for postoperative pain control after photorefractive keratectomy.

Key facts

Study ID

NCT01097577

Run by

59th Medical Wing

People needed

130

Starts

2010-03-01

Expected to finish

2010-06-01

Last updated by the study team

2020-10-28

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Healthy ocular status
• Stable preoperative refractive anisometropia
• Consented to the PRK surgical procedure

You may not qualify if…

• Pregnant or breastfeeding
• Diagnosed with autoimmune disease or diabetes
• Patients with a known adverse reaction or hypersensitivity to gabapentin or pregabalin
• Patients only desiring PRK on one eye
• Patients with history of drug use/abuse/addiction
• Patients who are on chronic pain medications
• Patients currently taking anti-epileptic, antidepressant and/or anti-psychotic medications
• Patients with a history of suicidality
• Patients with chronic renal insufficiency (defined as estimated creatinine clearance less than 30ml/min or Scr ≥ 2.0) 10) Patients who have experienced angioedema, or have heart failure

Where it is running

• Wilford Hall Medical Center - Refractive Surgery Center — Lackland Air Force Base, Texas, United States

Full record on ClinicalTrials.gov

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