Determination of the in Vitro Effects of Cationic Airway Lining Modulators (CALM) on Chronic Obstructive Pulmonary Disease (COPD) Sputum

Completed

Conditions studied: Chronic Obstructive Pulmonary Disease

In brief

This study is intended to be an evaluation of the properties of human sputum collected from patients with COPD. It is hypothesized that cationic airway lining modulators will have beneficial effects on the rheological properties of sputum derived from patients with COPD. Approximately 10 patients with COPD will collect sputum at home for 5 days. Samples will be collected and tested in laboratory tests.

Key facts

Study ID

NCT01096173

Run by

Pulmatrix Inc.

People needed

10

Starts

2010-04-01

Expected to finish

2010-10-01

Last updated by the study team

2011-04-11

Who can join

Age: 35 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical and spirometric diagnosis of COPD
• Smoking history of at least 10 pack yrs
• Sputum production of greater than 2 tablespoons per day by patient report.

You may not qualify if…

• a primary diagnosis of asthma or bronchiectasis
• a COPD exacerbation within 4 weeks
• Inability to comply with study procedures.

Where it is running

• VA WNY Healthcare System — Buffalo, New York, United States

Full record on ClinicalTrials.gov

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