Aliskiren in Patients With Idiopathic Membranous Nephropathy
Withdrawn before enrolling · Not applicable
Conditions studied: Idiopathic Membranous Nephropathy
In brief
The goal of this proposal is to conduct a pilot study to access the antiproteinuric effect of aliskiren in patients with idiopathic membranous nephropathy. Patients will be treated for 3 months with aliskiren aiming to achieve the maximum tolerated dose and blood pressure (\>100 but \<125 mmHg systolic BP \>75% of the readings).
Key facts
- Study ID
- NCT01093781
- Run by
- Mayo Clinic
- People needed
- 0
- Starts
- 2010-11-01
- Expected to finish
- 2011-12-01
- Last updated by the study team
- 2013-03-13
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Idiopathic MN proven by diagnostic kidney biopsy.
- Age ≥18 years but ≤ 80 years.
- Proteinuria as measured by urinary protein/urinary creatinine > 4.0 on a spot sample aliquot from a 24-hour urine collection.
- Estimated GFR ≥ 30 ml/min/1.73m\^2 using the 4 variable Modification of Diet in Renal Disease (MDRD) equation.
You may not qualify if…
- Age <18 years.
- Estimated Glomerular Filtration Rate (GFR) < 30 ml/min/1.73m\^2, or serum creatinine >3.0 mg/dl.
- Patient must be off prednisone, calcineurin inhibitor or mycophenolate mofetil for > 1 month and alkylating agents for > 6 months.
- Patients with presence of active infection or a secondary cause of MN (e.g. hepatitis B, HIV, systemic lupus erythematosus (SLE), medications, malignancies).
- Type 1 or 2 diabetes mellitus. Patients who have recent history of steroid induced diabetes but no evidence of diabetic nephropathy on renal biopsy performed within 6 months of entry into the study are eligible for enrollment.
- Pregnancy or nursing for safety reasons.
- Acute renal vein thrombosis documented prior to entry by renal US or CT scan.
- Previous therapy with Aliskiren
Where it is running
- Mayo Clinic in Rochester — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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