Chronotherapy Versus Conventional BP Control to Correct Abnormal Circadian BP Pattern in Kidney Transplant Recipients

Completed · Not applicable

Conditions studied: Blood Pressure Control, Kidney Transplant Recipient

In brief

The purpose of this study is to identify and manage factors related to blood pressure control that impact organ function and survival in kidney transplant recipients. Loss of the circadian (relating to a 24-hour rhythm) blood pressure pattern is common in kidney transplant recipients and is associated with poor allograft kidney function. It is still unclear if restoring the normal day-night blood pressure (BP) pattern will translate into better allograft outcome. Although studies in patients with and without chronic kidney disease indicate that restoration of the normal nocturnal (night) dipping in BP is possible by changing the timing of the BP medications to cover the overnight period (chronotherapy), this has not been tested in kidney transplant patients.

Key facts

Study ID

NCT01093703

Run by

Mayo Clinic

People needed

99

Starts

2008-12-01

Expected to finish

2012-11-01

Last updated by the study team

2013-05-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Recipient of a kidney transplant.
• Age≥18 years.
• Stable allograft function.
• Ability to give informed consent.

You may not qualify if…

• Multiorgan transplant recipients.
• Kidney transplant recipients with poor allograft function.
• Documented history of obstructive sleep apnea.

Where it is running

• Mayo Clinic — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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