Oral Versus Intravenous Hydration to Prevent Contrast Induced Nephropathy
Withdrawn before enrolling · Phase 4
Conditions studied: Contrast Induced Nephropathy
In brief
The increased risk for contrast-induced nephropathy (CIN) in patients with chronic kidney disease (CKD) undergoing coronary angiography (CAG) has been established. Current and historical data on CIN prevention strategies have shown wide variation with respect to the optimal type, route and timing of these therapies. We investigate the role for oral hydration and/or oral sodium bicarbonate administration compared to intravenous hydration and/or sodium bicarbonate in patients with CKD undergoing CAG.
Key facts
- Study ID
- NCT01093131
- Run by
- The Western Pennsylvania Hospital
- People needed
- 0
- Starts
- 2005-02-01
- Expected to finish
- 2010-02-01
- Last updated by the study team
- 2019-10-04
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Stable serum creatinine levels of at least 1.1 mg/dL or estimated creatinine clearance less than 60 mL/min
- Scheduled for diagnostic, elective cardiac angiography
You may not qualify if…
- Serum creatinine levels >8.0 mg/dL
- Change in serum creatinine levels of at least 0.5 mg/dL during the previous 24 hours
- Preexisting dialysis
- Multiple myeloma or other myeloproliferative disease
- Current CHF or recent history of flash pulmonary edema
- Current myocardial infarction
- Symptomatic hypokalemia
- Uncontrolled hypertension (treated systolic blood pressure >200 mmHg or diastolic blood pressure >100mmHg)
- Exposure to radiocontrast within 7 days the study
- Emergency Catheterization
- Allergy to radiographic contrast
- Pregnancy
- Administration of dopamine, mannitol, fenoldapam, or N-acetylcysteine during the time of the study
- Severe COPD
- Serum Bicarb > 28
- Sodium <133
Where it is running
- The Western Pennsylvania Hospital — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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