Safety of Phenylephrine for Oral Mucositis Prevention

Stopped early · Phase 1

Conditions studied: Mucositis, Stomatitis

In brief

The purpose of this study is to determine if applying the drug phenylephrine to the inside of the mouth can be done safely and is tolerable to use in cancer patients receiving radiation to the Sub-mandibular lymph nodes.

Key facts

Study ID

NCT01092975

Run by

University of Wisconsin, Madison

People needed

1

Starts

2010-03-01

Expected to finish

2011-04-01

Last updated by the study team

2020-12-28

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• cancer patients scheduled to receive at least 5 weeks of radiation therapy to the sub-mandibular lymph nodes
• normal ECG
• normal blood pressure

You may not qualify if…

• untreated cardiac disease
• connective tissue disorders
• open sores, wound, ulcerations to oral cavity
• allergy to phenylephrine
• know untreated hypertensin
• abnormal ECG in past 6 months
• taking prescription monoamine oxidase inhibitor (MAOI)
• are pregnant

Where it is running

• University of Wisconsin Carbone Cancer Center — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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