Study To Establish The Effects Of PF-04457845 On Sleep In Healthy Volunteers

Completed · Phase 1 · Has a placebo group

Conditions studied: Healthy, Sleep

In brief

PF-04457845 has been shown to temporarily decrease the dream (REM) period of sleep in rats, which suggests that PF-04457845 is active in rat's brains. This study is designed to see whether this is also the case in man.

Key facts

Study ID

NCT01092845

Run by

Pfizer

People needed

30

Starts

2010-04-01

Expected to finish

2010-06-01

Last updated by the study team

2018-12-04

Who can join

Age: 18 and older, up to 55. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Healthy male subjects between the ages of 18 and 55 years
• Body Mass Index (BMI) between 17.5 and 30.5 kg/m2
• Total body weight >50 kg

You may not qualify if…

• History of any active sleep disorder
• History of any sleep or circadian rhythm sleep disorder including RLS, narcolepsy, sleep apnea, phase advance or delay syndromes within the past 5 years
• Currently on or planning to be involved in night or rotating shift work or traveling across more than four time zones in 14 days prior to screening

Where it is running

• Pfizer Investigational Site — New York, New York, United States

Full record on ClinicalTrials.gov

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