Carboplatin as a Radiosensitizer in Treating Childhood Ependymoma

Stopped early · Phase 2

Conditions studied: Ependymoma

In brief

This is a phase II study evaluating the feasibility of concurrent carboplatin given with focal radiation therapy in children age 12 months to \< 21 years with newly diagnosed localized ependymoma who have no or minimal residual disease post-operatively (\< 0.5 cm). The hypothesis is that utilizing carboplatin as a radiosensitizer is feasible and tolerable and may improve event-free survival (EFS) and minimize local recurrences as compared to historic controls. Following a neurosurgical resection and staging, patients who meet the eligibility criteria will receive standard fractionated radiation therapy at doses of 54 to 59.4 Gy to the primary site depending upon age. All patients will receive 35 mg/m²/day of carboplatin prior to each fraction of radiotherapy. Although significant neutropenia is not anticipated, G-CSF will be administered per study guidelines during radiation if neutropenia occurs. All patients will be followed for toxicity, response (resolution of residual disease) and event-free survival (EFS). Patients' tumor sample, blood and cerebro-spinal fluid (CSF) will also be prospectively evaluated to quantify the level of Survivin, a known inhibitor of apoptosis, via immunohistochemistry, Western Blot Analysis (in tumor tissue) and ELISA (in blood and CSF). The feasibility of obtaining these levels prospectively and in real time will be evaluated.

Key facts

Study ID

NCT01088035

Run by

Ann & Robert H Lurie Children's Hospital of Chicago

People needed

75

Starts

2010-04-01

Expected to finish

2015-04-01

Last updated by the study team

2015-03-02

Who can join

Age: 1 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must be enrolled before treatment begins.
• Patients must be ≥ 12 months and < 22 years of age at the time of diagnosis.
• The target tumors are primary brain non-metastatic (M0) ependymomas tumors. Patients must have histologic verification of an ependymoma at diagnosis. Patients with the following world health organization (WHO) diagnoses will be eligible for this study:Ependymoma (Subtypes: cellular, papillary, clear cell and tanycytic) and Anaplastic Ependymoma
• Life expectancy of ≥ 8 weeks.
• Newly diagnosed ependymoma and must not have had any prior chemotherapy or radiotherapy.
• All patients must have:
• A pre-operative MRI scan of the brain with and without contrast. NOTE: CT scans are NOT sufficient for study eligibility since radiation therapy planning and responses will be based on MRI scans only.
• Post-operative head MRI scan with and without contrast (preferably within 72 hours post-operatively).
• Spinal MRI (T-1 weighted imaging with and without gadolinium) is required within 28 days of surgery if done post-operatively and within 14 days of surgery if done pre-operatively. For posterior fossa tumors, pre-operative MRI scans are preferred because surgically induced inflammation/blood can be difficult to distinguish from tumor.
• Lumbar CSF cytology examination obtained between 7 and 31 days following surgery.
• Adequate bone marrow function, defined as:
• Peripheral absolute neutrophil count (ANC) >1500/μL
• Platelet count ≥ 100,000/μL (transfusion independent)
• Hemoglobin ≥ 10.0 gm/dl (may receive RBC transfusions)
• Adequate renal function defined as:
• Serum creatinine < 1.5 times the upper limit of normal based on the patient's age, or creatinine clearance greater than 60 ml/min/1.73 m² corrected for age and body surface area.
• Adequate liver function defined as:
• Total bilirubin <1.5 x the institutional normal
• SGOT (AST) or SGPT (ALT) <2.5 x institutional normals.
• Patients must begin chemoradiotherapy within 56 days of definitive surgery.
• All patients and/or their parents or legal guardians must sign a written informed consent
• Patients must provide assent as per local IRB guidelines (if applicable).
• Patients and/or their families must consent to the mandatory biology studies, including serum Survivin levels, CSF Survivin levels, paraffin-embedded tissue and fresh-frozen tissue when available.
• Karnofsky/Lansky scoring greater than 50.
• Corticosteroid supportive care is permissible at the clinician's discretion prior to and during chemo-radiotherapy.

Where it is running

• Children's Memorial Hospital — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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