Phase II Trial of AUY922 vs. Comparators in Advanced Gastric Cancer

Completed · Phase 2

Conditions studied: Advanced Gastric Cancer, Gastro-esophageal Junction Cancer

In brief

A clinical trial to determine the effectiveness and safety of AUY922 compared to other drugs known to be effective against gastric cancer in second line therapy for patients who have failed one line of chemotherapy.

Key facts

Study ID

NCT01084330

Run by

Novartis Pharmaceuticals

People needed

68

Starts

2010-04-01

Expected to finish

2012-05-01

Last updated by the study team

2020-12-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Radiologically confirmed advanced gastric cancer
• One previous line of chemotherapy
• Progressive disease
• One measurable lesion
• Blood tests within protocol ranges
• (WHO) Performance Status ≤ 1
• Able to sign informed consent

You may not qualify if…

• No symptomatic brain metastases
• No coumarin type anticoagulants
• No liver or kidney disease
• No impaired heart function
• No pregnant or lactating women
• Other protocol-defined inclusion/exclusion criteria may apply

Where it is running

• USC/Kenneth Norris Comprehensive Cancer Center USC/Norris — Los Angeles, California, United States
• University of California at Los Angeles Dept. of UCLA (4) — Los Angeles, California, United States
• Horizon Oncology Center — Lafayette, Indiana, United States
• The Sidney Kimmel Cancer Center at Johns Hopkins Hospital Dept. of SKCC @ JHU — Baltimore, Maryland, United States
• Clinical Research Alliance Dept.ofArenaOncologyAssoc(2) — Lake Success, New York, United States
• Baylor Health Care System/Sammons Cancer Center Baylor Texas Oncology — Dallas, Texas, United States
• Tyler Cancer Center Dept.ofTylerCancerCtr. (2) — Tyler, Texas, United States
• Novartis Investigative Site — Adelaide, South Australia, Australia
• Novartis Investigative Site — Montreal, Quebec, Canada
• Novartis Investigative Site — Bordeaux, France
• Novartis Investigative Site — Lyon, France
• Novartis Investigative Site — Toulouse, France
• Novartis Investigative Site — Erlangen, Germany
• Novartis Investigative Site — Ulm, Germany
• Novartis Investigative Site — Genova, GE, Italy
• Novartis Investigative Site — Modena, MO, Italy
• Novartis Investigative Site — Pisa, PI, Italy
• Novartis Investigative Site — Roma, RM, Italy
• Novartis Investigative Site — Naples, Italy
• Novartis Investigative Site — Utrecht, Netherlands
• Novartis Investigative Site — Moscow, Russia
• Novartis Investigative Site — Moscow, Russia
• Novartis Investigative Site — Singapore, Singapore
• Novartis Investigative Site — Suwon, Gyeonggi-do, South Korea
• Novartis Investigative Site — Suwon, Gyeonggi-do, South Korea

Full record on ClinicalTrials.gov

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