Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training

Completed · Not applicable · Has a placebo group

Conditions studied: Sarcopenia, Osteoporosis, Aging

In brief

The purpose of this study is to determine if taking the pain reliever acetaminophen (ACET) interferes with some of the benefits of weight lifting on muscles and bone density in older men.

Key facts

Study ID

NCT01083901

Run by

University of Colorado, Denver

People needed

34

Starts

2006-05-01

Expected to finish

2011-03-01

Last updated by the study team

2013-06-24

Who can join

Age: 50 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• average use of acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) [including aspirin] less than 3 days per month
• not currently engaged in moderate-to-vigorous weight-lifting exercise
• non-smoker
• willing to participate in a supervised exercise program for 9 months

You may not qualify if…

• relative or absolute contraindications to regular use of acetaminophen or NSAIDs including known allergy or intolerance to either drug,history of peptic ulcer or GI bleeding, anemia, asthma with bronchospasm induced by aspirin or other NSAIDS, moderate or severe renal impairment, known hepatobiliary disease
• contraindications to exercise testing and training including congestive heart failure class III or IV, uncontrolled hypertension and unstable cardiovascular disease
• thyroid dysfunction
• orthopedic problems that limit the ability to perform vigorous exercise or increase the likelihood of the use of pain medications
• drugs known to alter bone metabolism
• allergy to lidocaine
• diabetes mellitus requiring pharmacologic therapy

Where it is running

• University of Colorado Denver — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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