Study to Compare the Efficacy and Safety of Olaparib When Given in Combination With Carboplatin and Paclitaxel, Compared With Carboplatin and Paclitaxel in Patients With Advanced Ovarian Cancer

Running, not enrolling · Phase 2

Conditions studied: Ovarian Cancer

In brief

To compare the efficacy of olaparib in combination with paclitaxel and carboplatin (AUC4) when compared with carboplatin (AUC6) and paclitaxel alone in patients with advanced ovarian cancer.

Key facts

Study ID

NCT01081951

Run by

AstraZeneca

People needed

162

Starts

2010-02-04

Expected to finish

2026-12-31

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older, up to 125. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with serous ovarian cancer
• Patients who have received no more than 3 previous platinum containing treatments and were progression free for at least 6 months following the end of the last platinum treatment
• At least one lesion that is suitable for accurate repeated measurements

You may not qualify if…

• Patients receiving any systemic anticancer chemotherapy, radiotherapy (except palliative) within two weeks from the last dose prior to study treatment
• Hypersensitivity to pre medications required for treatment with paclitaxel/carboplatin

Where it is running

• Research Site — West Hollywood, California, United States
• Research Site — Orlando, Florida, United States
• Research Site — Indianapolis, Indiana, United States
• Research Site — Boston, Massachusetts, United States
• Research Site — Boston, Massachusetts, United States
• Research Site — New York, New York, United States
• Research Site — Portland, Oregon, United States
• Research Site — Parkville, Australia
• Research Site — Randwick, Australia
• Research Site — Brussels, Belgium
• Research Site — Leuven, Belgium
• Research Site — Namur, Belgium
• Research Site — Wilrijk, Belgium
• Research Site — Vancouver, British Columbia, Canada
• Research Site — Hamilton, Ontario, Canada
• Research Site — Toronto, Ontario, Canada
• Research Site — Toronto, Ontario, Canada
• Research Site — Québec, Quebec, Canada
• Research Site — Sherbrooke, Quebec, Canada
• Research Site — Brno, Czechia
• Research Site — Brno, Czechia
• Research Site — Hradec Králové, Czechia
• Research Site — Olomouc, Czechia
• Research Site — Prague, Czechia
• Research Site — Stanford, California, United States

Full record on ClinicalTrials.gov

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