A Trial of Restrictive Versus Traditional Blood Transfusion Practices in Burn Patients
Completed · Not applicable
Conditions studied: Burn Injury
In brief
The purpose of this study is to find out if burn injured patients do better receiving fewer blood transfusions than what is traditionally given. We traditionally provide blood transfusions to maintain a hemoglobin level, which is an indicator of the level of red blood cells that carry oxygen in your body, to above 10 g/dl (g/dl stands for grams per deciliter and is the standard measurement used to indicate the level of red blood cells in your blood). However, a preliminary study indicated that maintaining the hemoglobin level to above 7-8 g/dl with less blood transfusion, as compared to a hemoglobin level of 10 g/dl and above, would reduce the occurrence of blood infection, duration on the respirator and length of hospital stay, yet would achieve similar survival in both groups.
Key facts
- Study ID
- NCT01079247
- Run by
- American Burn Association
- People needed
- 347
- Starts
- 2010-02-28
- Expected to finish
- 2016-09-28
- Last updated by the study team
- 2023-08-04
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- >20% TBSA burn with anticipated operation need on admission as determined by attending physician
- age >18 years
- Admission within 96 hours of injury
You may not qualify if…
- <18 years of age
- pregnancy
- inability or unwillingness to receive blood products
- history of chronic anemia (hemoglobin <9.0 g/dL one month prior to enrollment)
- preexisting need for hemodialysis
- brain death or imminent brain death
- non-survivable burn as determined by the attending burn surgeon
- angina or acute myocardial infarction
- preexisting hematologic disease
- Length of hospital stay anticipated to be < 2 weeks
- Transfusion administered at outside hospital before admit
Where it is running
- Maricopa Integrated Health System (Arizona Burn Center) — Phoenix, Arizona, United States
- Arrowhead Regional Medical Center — Colton, California, United States
- Community Regional Medical Center — Fresno, California, United States
- University of California Davis Medical Center-Regional Burn Center — Sacramento, California, United States
- University of California, San Diego — San Diego, California, United States
- Washington Hospital Burn Center — Washington D.C., District of Columbia, United States
- University of Florida Health Science — Gainesville, Florida, United States
- Doctors Hospital-Joseph M Still Burn Center — Augusta, Georgia, United States
- University of Kansas Medical Center — Kansas City, Kansas, United States
- University of North Carolina at Chapel Hill (Jaycee Burn Center) — Chapel Hill, North Carolina, United States
- Wake Forest University — Winston-Salem, North Carolina, United States
- Oregon Burn Center Legacy Health System — Portland, Oregon, United States
- University of Texas SouthWestern Medical Center — Dallas, Texas, United States
- U.S. Army Institute of Surgical Research (USAISR) — Fort Sam Houston, Texas, United States
- University of Utah Intermountain School of Medicine — Salt Lake City, Utah, United States
- University of Alberta — Edmonton, Alberta, Canada
- Sunnybrook Health Science Center — Toronto, Ontario, Canada
- New Zealand National Burn Centre-Middlemore Hospital — Auckland, New Zealand
Full record on ClinicalTrials.gov
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