Memantine in Adult Autism Spectrum Disorder
Stopped early · Not applicable · Has a placebo group
Conditions studied: Autism, Asperger's Disorder, Pervasive Developmental Disorder NOS
In brief
The purpose of this study is to see if memantine is helpful in managing problematic symptoms in adults with autism, Asperger's disorder, or Pervasive Developmental Disorder not otherwise specified (NOS).
Key facts
- Study ID
- NCT01078844
- Run by
- Johns Hopkins University
- People needed
- 4
- Starts
- 2010-02-01
- Expected to finish
- 2010-07-01
- Last updated by the study team
- 2017-07-26
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Participant is currently in treatment in the Johns Hopkins Bayview Medical Center (JHBMC)
- Participant has a diagnosis of:
- Autistic Disorder
- Asperger's Disorder
- Pervasive Developmental Disorder (PDD) NOS
- Participant meets one of the following criteria:
- CGI-S >= 4 (CGI-S: ________)
- Participant has the following problematic behaviors (at least one) that might be expected to benefit from memantine:
- _____________________________________________
- _____________________________________________
- _____________________________________________
You may not qualify if…
- The patient meets none of the following criteria (mark if absent):
- Active seizures (Patients with a history of seizures, who have been seizure-free on an antiepileptic regimen for six months or more would be eligible).
- Rett's Syndrome or Childhood Disintegrative Disorder
- Active treatment with an acetylcholinesterase inhibitor
- Prior or current treatment with memantine
- Current treatment with lamotrigine
- Genetic, metabolic or degenerative disorder (excepting Fragile X).
- Brain malformation or known severe brain trauma
- Pregnancy or breastfeeding
- Glomerular Filtration Rate (GFR) < 30 mL/min
Where it is running
- Johns Hopkins Bayview — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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