Smoking-Cessation and Stimulant Treatment (S-CAST)

Completed · Phase 3

Conditions studied: Cocaine Dependence, Methamphetamine Dependence, Nicotine Dependence

In brief

The primary objective of this study is to evaluate the impact of substance-abuse treatment as usual plus smoking-cessation treatment (TAU+SCT), relative to substance-abuse treatment as usual (TAU), on drug-abuse outcomes. Specifically, this study will evaluate whether concurrent smoking-cessation treatment improves, worsens, or has no effect on stimulant-use outcomes in smokers who are in outpatient substance-abuse treatment for cocaine or methamphetamine dependence.

Key facts

Study ID

NCT01077024

Run by

University of Cincinnati

People needed

538

Starts

2010-02-01

Expected to finish

2012-08-01

Last updated by the study team

2021-09-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of cocaine/methamphetamine dependence
• Smoked cigarettes for at least 3 months
• Currently smoking > 6 cigarettes/day
• Have an interest in quitting smoking
• Enrolled in outpatient treatment at a participating site

You may not qualify if…

• Clinical diagnosis of current alcohol or sedative dependence, bipolar disorder; or a life-time diagnosis of anorexia nervosa or bulimia
• Seeking/receiving treatment for opiate-agonist replacement therapy
• Medical conditions that could compromise participant safety
• Taking medications with known/potential interactions with bupropion
• Hypersensitivity to bupropion, nicotine, or menthol
• Pregnant or breastfeeding
• Abnormal ECG
• Recent smoking cessation treatment
• Use of tobacco products other than cigarettes in the past week
• Likely to enter residential/inpatient treatment within 10 weeks
• Have all stimulant-positive urine drug screens during screening/baseline

Where it is running

• La Frontera — Tucson, Arizona, United States
• Matrix Institute on Addictions — Rancho Cucamonga, California, United States
• Tarzana Treatment Centers — Tarzana, California, United States
• Gateway — Jacksonville, Florida, United States
• Gibson Recovery Center, Inc. — Cape Girardeau, Missouri, United States
• Maryhaven — Columbus, Ohio, United States
• ADAPT — Roseburg, Oregon, United States
• Addiction Medicine Services — Pittsburgh, Pennsylvania, United States
• Lexington/Richland Alcohol and Drug Abuse Council — Columbia, South Carolina, United States
• Behavioral Health Services of Pickens County — Pickens, South Carolina, United States
• Dorchester — Summerville, South Carolina, United States
• Nexus Recovery Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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