Predictors of Rates of Resistant Gram-Negative Bacteria

Completed

Conditions studied: Relationship of Carbapenem Use to Carbapenem Resistant Gram-negative Bacteria

In brief

Antibiotic resistance in gram-negative bacteria continues to increase in US hospitals. This comes at a time when there are few new drugs in development that are active for these resistant organisms. The implication is that we must learn to use the drugs that we have more wisely and develop new strategies that will preserve existing agents. Antimicrobial "stewardship" programs are one strategy that many hospitals are adopting to improve the quality of antimicrobial use. The goal of this project is to develop a consortium of US academic medical centers that will allow characterization of the relationships between antibiotic use and rates of resistance for gram-negative pathogens, and to help hospital devise new strategies that will modify antibiotic use and possibly delay or reduce resistance. The specific hypotheses are: * Hospitals with established or emerging resistance in gram-negative pathogens, including extended spectrum beta-lactamase (ESBL) producing organisms, carbapenem-resistant enterobacteriaceae (CRE)and carbapenem-resistant P. aeruginosa have a different pattern of antimicrobial drug use compared to hospitals with fewer of these organisms. * Hospital use of ertapenem is not associated with the rates of carbapenem-resistant organisms.

Key facts

Study ID
NCT01075009
Run by
Virginia Commonwealth University
People needed
36
Starts
2010-02-01
Expected to finish
2013-05-01
Last updated by the study team
2014-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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