Chronic Obstructive Pulmonary Disease (COPD) Activity: Serotonin Transporter (SERT), Cytokines and Depression (CASCADE Study)

Status unconfirmed

Conditions studied: Chronic Obstructive Pulmonary Disease

In brief

The goal of the study is to look at how genes and certain chemicals in the body are related to depression and chronic obstructive pulmonary disease.

Key facts

Study ID

NCT01074515

Run by

University of Washington

People needed

350

Starts

2010-02-01

Expected to finish

2016-02-01

Last updated by the study team

2015-12-03

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of COPD confirmed by the following: 1) FEV1/FVC < 70%; 2) Moderate to very severe disease by GOLD criteria (FEV1 <65%); 2) Age > 40 years; and 3) A significant history of current or past cigarette smoking (> 10 pack-years);
• Stable disease with no acute exacerbations of COPD in the past 4 weeks;
• Ability to speak, read and write English

You may not qualify if…

• Acute COPD exacerbation within the past 4 weeks (temp exclusion)
• Chronic obstructive lung disorders unrelated to COPD: asthma, bronchiectasis, cystic fibrosis
• Idiopathic Pulmonary Fibrosis
• Congestive Heart Failure
• Chronic renal failure requiring dialysis
• Primary pulmonary vascular disease
• Chronic inflammatory, infectious or auto-immune disease, e.g. osteomyelitis, crohn's disease or rheumatoid arthritis
• Chronic liver disease
• Metastatic cancer
• Chronic antibiotic use or ongoing infection
• Chronic oral prednisone use
• Moderate to severe dementia
• Severe primary mental illness, e.g. schizophrenia, bipolar disease, severe obsessive compulsive disorder
• <2 years life expectancy
• History of fainting with spirometry

Where it is running

• South Texas Veterans Health Care System — San Antonio, Texas, United States
• The University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
• Puget Sound Veterans Administration Health Care System — Seattle, Washington, United States
• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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