Study to Determine the Digestive and Physiological Effects of an Extract From Bran in Healthy Men and Women

Completed · Phase 4

Conditions studied: Healthy

In brief

The primary objective of this trial is to determine whether two doses of an extract from bran demonstrate a prebiotic effect on colonic bacteria (by modulating selected fecal microbial populations, particularly bifidobacteria). The secondary objective is to measure the potential beneficial effects of consuming an extract from bran on the following physiological parameters: laxation, fecal pH, fecal moisture and stool consistency, blood glucose and insulin concentrations, plasma lipid profiles and serum free fatty acids, colonic bacterial short chain fatty acid production, ammonia metabolism and protein degradation, and biomarkers of oxidative stress and inflammation.

Key facts

Study ID

NCT01073969

Run by

Kellogg Company

People needed

65

Starts

2009-03-01

Expected to finish

2009-08-01

Last updated by the study team

2010-02-23

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female
• 18-75 years of age
• Body mass index ≥18.5 and <35.0 kg/m2
• Fasting LDL-C level ≥100 mg/dL and <200 mg/dL
• Otherwise judged to be in good health, willing to maintain habitual food and beverage intake and physical activity patterns throughout the trial

You may not qualify if…

• Significant gastrointestinal condition
• Use of pre/probiotic foods or supplements
• Use of antibiotics
• Pregnancy
• Certain muscle, liver, kidney, lung or gastrointestinal conditions and medications
• Poorly controlled hypertension
• Cancer treated within prior 2 years

Where it is running

• Provident CRC — Glen Ellyn, Illinois, United States

Full record on ClinicalTrials.gov

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