Cerebellar rTMS for the Treatment of Schizophrenic Patients

Completed · Not applicable

Conditions studied: Schizophrenia

In brief

The primary aim of this protocol is to determine whether the use of repetitive transcranial magnetic stimulation (rTMS) over vermis of the cerebellum may be safe and therapeutically effective in patients with schizophrenia. Because this is the first evaluation of this treatment in this population, the focus of this study is safety.

Key facts

Study ID

NCT01072617

Run by

Beth Israel Deaconess Medical Center

People needed

8

Starts

2008-02-01

Expected to finish

2009-04-01

Last updated by the study team

2017-06-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age between 18-65 years
• Diagnosis of schizophrenia according to DSM-IV criteria(by a board-certified psychiatrist)

You may not qualify if…

• Prior neurosurgical procedures
• Any history of seizure
• Previous head injury
• Contraindication to TMS:
• Implanted pacemaker
• Medication pump
• Vagal stimulator
• Deep brain stimulator
• Metallic hardware in the head or scalp: shrapnel, surgical clips, or fragments from welding
• Signs of increased intracranial pressure
• TENS unit and ventriculo-peritoneal shunt
• Pregnancy or lactating; note that a negative pregnancy test will be required if the patient is a female in reproductive years
• Advanced liver, kidney, cardiac, or pulmonary disease as defined clinically or a terminal medical diagnosis consistent with survival < 1 year
• A history of significant alcohol or drug abuse in the prior six months
• No focal cortical insult can be present, including tumor or vascular malformation
• Patients may not be actively enrolled in a separate intervention study
• Patients unable to undergo a brain MR:
• a. claustrophobia refractory to anxiolytics ferromagnetic metal in the body such as a prosthetic heart valve, a pacemaker, or a brain aneurysm clip).
• Change in antipsychotic medication during the last 4 weeks
• Any emergency psychiatry department visit during the last 4 weeks
• Been an inpatient in a psychiatry clinic within the last month
• Any other axis I diagnosis

Where it is running

• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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