Effect of Exercise on Endothelial Function and Vascular Compliance in Chronic Kidney Disease
Completed · Not applicable
Conditions studied: Kidney Failure, Chronic
In brief
The study hypothesis is that 6 weeks of repetitive handgrip exercise will improve endothelial function and venous compliance in pre-dialysis patients with an estimated glomerular filtration rate of less than or equal to 20 ml/min. If proven correct then arm exercise might be useful to improve the success rate for a surgically created arteriovenous fistula in the forearm to become usable as a vascular access for hemodialysis.
Key facts
- Study ID
- NCT01068314
- Run by
- University of Iowa
- People needed
- 12
- Starts
- 2007-01-01
- Expected to finish
- 2010-06-01
- Last updated by the study team
- 2014-02-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age exceeding the age of majority (18 years of age).
- Chronic renal failure with a calculated GFR (MDRD equation) less than or equal to 20 ml/min
- Eligible for creation of an arteriovenous fistula for the purpose of hemodialysis.
- The subject is expected to stay within driving distance of study site for at least 4 months.
- The subject's physician(s) will allow the patient to participate.
- Ability to give informed consent.
You may not qualify if…
- Unstable angina.
- Uncontrolled hypertension (resting blood pressure >170 systolic or >100 diastolic).
- Musculoskeletal or neurologic problem that prevents arm exercise.
- Currently functioning arteriovenous access in the same arm as the planned new fistula.
- Subjects who are eligible to participate in the ongoing DAC fistula trial.
- Planned new access surgery in less than 6 weeks
- Anticipated non-compliance with medical care based on physician judgment.
- Patient refusal.
Where it is running
- University of Iowa General Clinical Research Center — Iowa City, Iowa, United States
Full record on ClinicalTrials.gov
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