Cognitive Enhancement and Relapse Prevention in Cocaine Addiction

Completed · Not applicable · Has a placebo group

Conditions studied: Cocaine Addiction

In brief

For this project, the investigators are interested in exploring a new way to extend and maintain drug abstinence in people who are addicted to crack cocaine. This study will combine a medication called D-Cycloserine (DCS) and weekly cognitive behavioral therapy (CBT) to assess whether the combination will enhance people's ability to stay clean (drug free) for longer periods of time. One of the greatest risks for drug relapse is drug craving. Oftentimes drug craving occurs when a person is confronted with stressors and reminders of past drug use behavior. DCS has been shown to enhance the learning of new information. By administering DCS prior to learning new techniques such as how to cope with drug craving and drug-use reminders, it is possible that patients can be more successful at living a drug free life for a longer period of time. In addition to exploring this model behaviorally, the investigators will explore changes that may occur in the brain before and after the therapy/medication intervention. A technique called MRI (Magnetic Resonance Imaging) will be used to identify areas of the brain that are being activated during an attention task. Areas of neural activation will be assessed at study entry, end of therapy (4-week endpoint) and one month following completion of the treatment program.

Key facts

Study ID

NCT01067846

Run by

University of Arkansas

People needed

85

Starts

2010-06-01

Expected to finish

2012-01-01

Last updated by the study team

2013-11-26

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Eligible subjects must be cocaine-dependent persons between 18 and 65 years

You may not qualify if…

• Any current Axis-I psychiatric diagnosis other than cocaine or alcohol dependence or nicotine use
• Any current or prior neurological disease, history of a major medical illness, or current use of psychotropic medications
• Positive history of loss of consciousness of greater than 10 min
• Significant current or prior cardiovascular disease (hypertension, arrhythmias) that is not medically stable
• History of hospitalization within the previous six months for a medical illness
• Deafness, blindness or other significant sensory impairment.
• Contraindications for D-cycloserine and magnetic resonance imaging.

Where it is running

• Psychiatric Research Institute (PRI) (Center for Addiction Research (CAR) and Brain Imaging Research Center (BIRC)) University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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