Enhanced Firefighter Rehab Trial: The Role of Aspirin in Preventing Heat Stress Induced Platelet Activation
Completed · Not applicable · Has a placebo group
Conditions studied: Heat Stress Disorders
In brief
The purpose of this study is to determine if aspirin taken by firefighters prevents platelets from becoming sticky when body temperature rises during work in protective clothing.
Key facts
- Study ID
- NCT01066923
- Run by
- Dave Hostler
- People needed
- 124
- Starts
- 2010-02-01
- Expected to finish
- 2011-06-01
- Last updated by the study team
- 2017-11-13
Who can join
Age: 18 and older, up to 49. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Apparently healthy males and females aged 18-49 years
You may not qualify if…
- History of heart disease, vascular disease, or sudden death including prior MI, coronary revascularization, congenital heart disease or history of stroke
- Hypertension during screening: SBP>139 or DBP>89
- Those who are taking medications that may be expected to blunt the physiologic response to a treadmill exercise test (e.g. beta blockers)
- Prescription medication with known side effect of impaired thermoregulation
- Positive pregnancy test at any time during the study
- Resting ECG with clinical presentation suggesting coronary heart disease (e.g. pathologic Q wave)
- Known history of gastrointestinal disease or disorder i.e. diverticulitis which creates a theoretical risk of the core temperature capsule becoming lodged in the digestive tract
- Medications and supplements known to alter endothelial function (e.g. arginine, omega 3 fatty acids, NSAIDS, tobacco products. This exclusion may be disregarded for subjects willing to stop taking the supplement for the duration of the study
- At the discretion of the study physician for any other medical condition or prescription medication
- Known history of platelet dysfunction
- Aspirin allergy or intolerance
Where it is running
- University of Pittsburgh, Emergency Responder Human Performance Lab — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.