The Effects of Hydrocortisone in Endotoxemia in Normal Volunteers

Completed · Phase 1 · Has a placebo group

Conditions studied: Infections

In brief

Corticosteroids are substances produced by the adrenal gland to help the body fight against infection or injury. Hydrocortisone is a man-made form of this substance. Endotoxin is a man-made substance, which causes the body to "mimic" sickness(fever,chills,and achiness)for a few hours. This study is designed to give hydrocortisone before and after Endotoxin to determine if this medication can prevent or relieve any of the symptoms caused by the Endotoxin.

Key facts

Study ID

NCT01064986

Run by

Rutgers, The State University of New Jersey

People needed

12

Starts

2010-02-01

Expected to finish

2012-12-01

Last updated by the study team

2014-05-22

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• General good health as demonstrated by medical history, physical\& laboratory tests
• Age between 18 and 40 years
• Written informed consent prior to the performance of any study related procedures

You may not qualify if…

• History of cancer, rheumatoid arthritis, or immunological, renal, hepatic, endocrine, neurologic, heart disease or hypertension
• Any medication taken in past 48 hrs (except birth control)
• Recent history of alcohol or drug abuse
• Unable to provide written informed consent
• Exposure to any experimental agent or procedure within 30 days of study
• Pregnant or breast-feeding

Where it is running

• Rutgers-RWJMS — New Brunswick, New Jersey, United States

Full record on ClinicalTrials.gov

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