A Study To Explore The Effect On Inflammatory Markers After Nasal Allergen Challenge In Subjects With Seasonal Allergic Rhinitis And The Effect Of A Single Dose Of Ibuprofen Or Fluticasone Propionate On The Allergen Response.

Completed · Phase 1 · Has a placebo group

Conditions studied: Allergic Rhinitis

In brief

After a nasal allergen challenge it should be possible to measure markers of inflammation that may be useful to assess the properties of future drugs. If these markers are reproducible and impacted by the study drugs they could be useful for future drug development.

Key facts

Study ID

NCT01064726

Run by

Pfizer

People needed

18

Starts

2009-10-01

Expected to finish

2010-04-01

Last updated by the study team

2010-06-02

Who can join

Age: 19 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female subjects with seasonal allergic rhinitis (out of season).
• Sensitive to ragweed skin prick test and screening nasal allergen challenge.

You may not qualify if…

• Subjects with significant concomitant diseases.
• Subjects with symptoms of allergic rhinitis in 2 weeks prior to screening.
• Female subjects that are pregnant or nursing. Subjects with hypersensitivity to study drugs or allergen challenge.

Where it is running

• Pfizer Investigational Site — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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