Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma

Running, not enrolling · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Epithelioid Mesothelioma, Pleural Malignant Mesothelioma, Recurrent Malignant Mesothelioma, Sarcomatoid Mesothelioma

In brief

This randomized phase I/II trial is studying the side effects and best dose of cediranib maleate when given together with pemetrexed disodium and cisplatin and to see how well it works in treating patients with malignant pleural mesothelioma. Drugs used in chemotherapy, pemetrexed disodium and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cediranib maleate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Giving pemetrexed disodium and cisplatin together with cediranib maleate may kill more tumor cells.

Key facts

Study ID: NCT01064648
Run by: National Cancer Institute (NCI)
People needed: 117
Starts: 2010-03-15
Expected to finish: 2027-03-31
Last updated by the study team: 2026-08-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patient must have histologically or cytologically confirmed diagnosis of malignant pleural mesothelioma; surgical resection must not be planned
Patients must have measurable or non-measurable disease by both RECIST and modified RECIST criteria for pleural tumors as documented by computed tomography (CT) scan; examinations for assessment of measurable disease must have been completed within 28 days prior to registration; examinations for assessment of non-measurable disease must have been performed within 42 days prior to registration; all disease must be assessed and documented on the RECIST 1.1 and Modified RECIST Baseline Tumor Assessment Form
Patients must not have received any prior systemic therapy (chemotherapy or other biologic therapy) for their unresectable malignant pleural mesothelioma; prior systemic chemotherapy or biologic therapy is allowed as neoadjuvant or adjuvant treatment, disease has now recurred, and all systemic treatment was completed > 6 months prior registration; prior therapy must not have included cediranib
Patients may have received prior surgery (e.g., pleurectomy, pleurodeisis) provided at least 28 days have elapsed since surgery (thoracic or other major surgeries) and patients have recovered from all associated toxicities at the time of registration; there must be no anticipated need for major surgical procedures during protocol treatment
Patients may have received prior radiation therapy provided at least 28 days have elapsed since the last treatment and patients have recovered from all associated toxicities at the time of registration
Institutions must seek additional patient consent for the banking and future use of specimens
Patient must have Zubrod performance status 0-2
Absolute neutrophil count >= 1,500 mcl
Platelets >= 100,000/ml
Hemoglobin >= 9.0 g/dl (may be reached by transfusion)
Total bilirubin =< 1.5 x institutional upper limit of normal (IULN)
Serum glutamic oxaloacetic transaminase (SGOT) or serum glutamate pyruvate transaminase (SGPT) =< 2.5 x ULN (if liver metastases are present, SGOT or SGPT must be =< 5.0 x IULN)
Serum creatinine =< 1.5 x IULN
Calculated creatinine clearance >= 60 mL/min
Urine protein must be screened by urine analysis within 28 days prior to registration; patient must not have greater than +1 proteinuria on two consecutive dipsticks taken no less than 7 days apart; however, if the first urinalysis shows no protein, then a repeat urinalysis is not required
Patient must have an electrocardiogram (ECG) performed within 42 days prior to registration; patient must not have mean corrected QT (QTc) > 500 msec (with Bazett's correction) in screening electrocardiogram, or other significant ECG abnormality, New York Heart Association (NYHA) classification III or IV; patient must not require concurrent use of drugs or biologics with proarrhythmic potential
Patient must not be receiving any medication that may markedly affect renal function (e.g., vancomycin, amphotericin, pentamidine)
Patient must not have had clinically significant hemoptysis, defined as greater than 1 tablespoon of bright red blood, within one year prior to registration; although hemoptysis has not been associated with cediranib, it may be a class effect for anti-angiogenic agents and therefore a risk factor for this experimental agent
Patient must be able to swallow oral medications
Patients must not have known human immunodeficiency virus (HIV) infection
Patients must not be pregnant or nursing; women/men of reproductive potential must have agreed to use an effective contraceptive method; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
Patient must have no plans to receive concurrent chemotherapy, hormonal therapy, radiotherapy, immunotherapy or any other type of therapy for treatment of cancer while on this protocol treatment
No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for five years

Where it is running

Kaiser Permanente-Deer Valley Medical Center — Antioch, California, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank, California, United States
Kaiser Permanente-Fremont — Fremont, California, United States
Kaiser Permanente-Fresno — Fresno, California, United States
Los Angeles General Medical Center — Los Angeles, California, United States
USC / Norris Comprehensive Cancer Center — Los Angeles, California, United States
Kaiser Permanente-Modesto — Modesto, California, United States
Kaiser Permanente-Oakland — Oakland, California, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange, California, United States
Kaiser Permanente-Redwood City — Redwood City, California, United States
Kaiser Permanente-Richmond — Richmond, California, United States
Kaiser Permanente-Roseville — Roseville, California, United States
University of California Davis Comprehensive Cancer Center — Sacramento, California, United States
Kaiser Permanente-South Sacramento — Sacramento, California, United States
Kaiser Permanente Sacramento Medical Center — Sacramento, California, United States
Kaiser Permanente-San Francisco — San Francisco, California, United States
Kaiser Permanente-Santa Teresa-San Jose — San Jose, California, United States
Kaiser Permanente San Leandro — San Leandro, California, United States
Kaiser Permanente-San Rafael — San Rafael, California, United States
Kaiser Permanente Medical Center - Santa Clara — Santa Clara, California, United States
Kaiser Permanente-Santa Rosa — Santa Rosa, California, United States
Kaiser Permanente-South San Francisco — South San Francisco, California, United States
Kaiser Permanente-Stockton — Stockton, California, United States
Kaiser Permanente Medical Center-Vacaville — Vacaville, California, United States
Highlands Oncology Group - Rogers — Rogers, Arkansas, United States

Full record on ClinicalTrials.gov

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