Study of a Screening Blood Test to Determine Patients' Potential Risk of Adenomatous or Advanced Colon Polyps (ACPs)

Completed

Conditions studied: Colonic Polyp

In brief

The aim of this study is to develop a blood test to determine which patients are at risk for pre-cancerous colon polyps (ACPs: Advanced Colon Polyps). The telomere length of peripheral blood lymphocytes (PBLs) can be measured from a blood sample. Mechanistic pathways and the investigator's preliminary data support PBL telomere length as a biomarker for ACPs. The long-term goal of this project is to decrease deaths from colon cancer by using a blood test to target colonoscopy for those patients who are at high risk for pre-cancerous polyps.

Key facts

Study ID

NCT01062035

Run by

Mayo Clinic

People needed

72

Starts

2010-01-01

Expected to finish

2013-09-01

Last updated by the study team

2014-06-26

Who can join

Age: 50 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Advanced Colon Polyp Group (ACP):
• Must be 50 to 60 years of age with an advanced colon polyp (ACP: advanced colon polyps are those larger than 10 mm, or a colon polyp with high grade dysplasia, or a colon polyp with villous features.
• Control Group (Controls):
• Must be 50 to 60 years of age and have had a negative screening colonoscopy.
• Controls will also have no history of adenomatous colorectal neoplasia.

You may not qualify if…

• Subjects under 50 years of age
• Subjects over 60 years of age
• Subjects with colon polyps less than 10 mm in size

Where it is running

• Mayo Clinic Jacksonville — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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