Temsirolimus in Treating Patients With Recurrent or Persistent Cancer of the Uterus

Stopped early · Phase 2

Conditions studied: Recurrent Uterine Sarcoma, Uterine Carcinosarcoma

In brief

This phase II trial is studying how well temsirolimus works in treating patients with recurrent or persistent cancer of the uterus. Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Key facts

Study ID

NCT01061606

Run by

National Cancer Institute (NCI)

People needed

8

Starts

2010-01-01

Expected to finish

2012-10-01

Last updated by the study team

2016-11-09

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Histologically or cytologically confirmed Carcinosarcoma (MMMT)
• Measurable disease;
• Only one prior systemic treatments after primary adjuvant treatment for persistent or metastatic disease are permitted,
• Radiation therapy (adjuvant or palliative) must be completed ≥ 4 weeks prior to registration
• Required laboratory values obtained =< 7 days prior to registration:
• Absolute Neutrophil Count (ANC) >= 1500/mm\^3
• Platelets >= 75,000/mm\^3
• Hemoglobin >= 9.0 g/dL
• Direct bilirubin =< 1.5 x upper limit of normal (ULN)
• Alkaline phosphatase =< 2.5 x ULN (≤ 5 x ULN if liver metastasis is present)
• SGOT(AST) =< 2.5 x ULN (≤ 5 x ULN if liver metastasis is present)
• Creatinine =< 1.5 x ULN
• Fasting serum cholesterol ≤ 350mg/dL (9.0 mmol/L)
• Triglycerides ≤ 1.5 x ULN
• Patients with Triglyceride levels > 1.5 x ULN can be started on lipid lowering agents and reevaluated within 1 week; if levels go to ≤ 1.5 x ULN, they can be considered for the trial and continue the lipid lowering agents
• International Normalized Ratio (INR) ≤ 1.5 (unless the patient is on full dose warfarin)
• ECOG Performance Status (PS) 0-1
• Capable of understanding the investigational nature, potential risks and benefits of the study and able to provide valid informed consent
• Full-dose anticoagulants, if a patient is receiving full-dose anticoagulants, the following criteria should be met for enrollment:
• The subject must have an in-range INR (usually between 2 and 3) on a stable dose of warfarin or on stable dose of LMW heparin
• Patients who have had prior anthracycline must have a normal ejection fraction on LVEF assessment by MUGA or Echo ≤ 4 weeks prior to registration
• Availability of tissue samples or blocks (from the primary tumor or metastases) for tumor studies
• Willingness to donate blood for correlative marker studies

You may not qualify if…

• Prior therapy with Temsirolimus or another mTOR inhibitors
• Patients cannot be receiving enzyme-inducing antiepileptic drugs (EIAEDs; e.g., phenytoin, carbamazepine, phenobarbital) nor any other CYP3A4 inducer such as rifampin or St. John's wort
• Untreated central nervous system (CNS) metastases; exceptions: patients with known CNS metastases can be enrolled if the brain metastases have been adequately treated and there is no evidence of progression or hemorrhage after treatment as ascertained by clinical examination and brain imaging (MRI or CT) ≤ 12 weeks prior to registration and no ongoing requirement for steroids
• Anticonvulsants (stable dose) are allowed
• Patients who had surgical resection of CNS metastases or brain biopsy ≤ 3 months prior to registration will be excluded
• Pregnant or lactating wome
• Currently active, second malignancy other than non-melanoma skin cancers; - Other uncontrolled serious medical or psychiatric condition (e.g. cardiac arrhythmias, diabetes, etc.)
• Active infection requiring antibiotics
• Received prior radiotherapy to any portion of the abdominal cavity or pelvis OTHER THAN for the treatment of endometrial cancer
• Radiation therapy to > 50% of marrow bearing areas

Where it is running

• Tower Cancer Research Foundation — Beverly Hills, California, United States
• City of Hope — Duarte, California, United States
• Los Angeles County-USC Medical Center — Los Angeles, California, United States
• City of Hope Medical Group Inc — Pasadena, California, United States
• University of California at Davis Cancer Center — Sacramento, California, United States
• University of Connecticut — Farmington, Connecticut, United States
• Yale University — New Haven, Connecticut, United States
• Morristown Memorial Hospital — Morristown, New Jersey, United States
• The Valley Hospital-Luckow Pavilion — Paramus, New Jersey, United States
• Women's Cancer Care Associates LLC — Albany, New York, United States
• Beth Israel Medical Center — New York, New York, United States
• New York University Langone Medical Center — New York, New York, United States
• Saint Luke's Roosevelt Hospital Center - Roosevelt Division — New York, New York, United States
• Presbyterian-Weill Medical College — New York, New York, United States
• Mount Sinai School of Medicine — New York, New York, United States
• Children's Hospital of New York Presbyterian — New York, New York, United States
• Columbia University College of Physicians and Surgeons — New York, New York, United States
• Montefiore Medical Center - Moses Campus — The Bronx, New York, United States
• Penn State Hershey Children's Hospital — Hershey, Pennsylvania, United States
• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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