Pazopanib + Vinorelbine in Non Small Cell Lung Cancer (NSCLC) and Breast Cancer
Stopped early · Phase 1
Conditions studied: Metastatic Non Small Cell Lung Cancer, Metastatic Breast Cancer
In brief
The purpose of this study is to determine the highest dose of Vinorelbine and Pazopanib that can be given together without causing severe side effects. Also, this study will evaluate what effects (good and bad) that the treatment has on patients and their cancer.
Key facts
- Study ID
- NCT01060514
- Run by
- Northwestern University
- People needed
- 8
- Starts
- 2010-02-01
- Expected to finish
- 2013-09-01
- Last updated by the study team
- 2013-10-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age > 18 years
- Patients must have diagnosis of breast cancer or non small cell lung cancer
- Patients must have evaluable disease
- Women of childbearing potential and sexually active males must commit to the use of effective contraception while on study.
- Patients must have given signed, informed consent prior to registration on study.
You may not qualify if…
- Patients must not be pregnant and/or lactating.
- Patients must not be receiving any other investigational agents.
- No prior exposure to vinorelbine or other VEGF inhibitors as treatment for metastatic disease
- Patients must not have received prior therapy (including radiation, surgery, and/or chemotherapy) within 30 days
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to pazopanib or vinorelbine.
- Patients cannot have received more than 2 prior chemotherapy regimens for lung cancer or 3 prior chemotherapy regimens for breast cancer. This criterion can be discussed further with the study doctor.
- Must not have uncontrolled illness including, but not limited to: ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmic, psychiatric illness/social situations that would limit compliance with study requirements.
Where it is running
- Northwestern University, Northwestern Medical Faculty Foundation — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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