Role of Skeletal Muscle Nitric Oxide Production in Age-related Fatigue and Fatigability
Completed · Not applicable · Has a placebo group
Conditions studied: Fatigue, Aging
In brief
This is a pilot study funded by the National Institutes of Health. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on muscle strength and physical function in older individuals. We propose to test a new method that may enable simultaneous determination of both vascular and skeletal muscle NO production for the first time in humans. Further, we will determine whether augmentation of NO-mediated responses, by administration of sildenafil citrate (Viagra), reduces fatigue and fatigability in older individuals.
Key facts
- Study ID
- NCT01059994
- Run by
- The University of Texas Medical Branch, Galveston
- People needed
- 12
- Starts
- 2010-01-01
- Expected to finish
- 2013-07-01
- Last updated by the study team
- 2019-02-11
Who can join
Age: 20 and older, up to 80. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- 1. Age 20-35 yrs, and 60-80 yrs.
- 2. Ability to sign consent form (score >23 on the 30-item Mini Mental State Examination, MMSE)
- 3. Stable body weight for at least 3 months
You may not qualify if…
- 1. Physical dependence or frailty (impairment in any of the Activities of Daily Living (ADL), history of falls (>2/year) or significant weight loss in the past year)
- 2. Exercise training (>2 weekly sessions of moderate to high intensity aerobic or resistance exercise)
- 3. Pregnancy
- 4. Significant heart, liver, kidney, blood or respiratory disease
- 5. Peripheral vascular disease
- 6. Diabetes mellitus or other untreated endocrine disease
- 7. Active cancer
- 8. Use of nitrates
- 9. Recent (within 6 months) treatment with anabolic steroids, or corticosteroids.
- 10. Alcohol or drug abuse
- 11. Severe depression (>5 on the 15-item Geriatric Depression Scale, GDS)
- 12. Cardiac abnormalities such as a cardiac shunt or previously diagnosed pulmonary hypertension.
- 13. Systolic blood pressure <100 or >150, diastolic blood pressure <60 or >90.
Where it is running
- University of Texas Medical Branch — Galveston, Texas, United States
Full record on ClinicalTrials.gov
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