Outcome Following Carbon Monoxide Poisoning in Children

Stopped early

Conditions studied: Carbon Monoxide Poisoning

In brief

Carbon monoxide poisoning is common. Many adults with CO poisoning have long-term, even permanent brain injury following poisoning. However, very little is known about the long-term outcome of children with carbon monoxide (CO) poisoning. In this study we plan to perform cognitive (thinking) and vestibular (balance) testing in children (ages 6 to 16)at 6 weeks and 6 months following CO poisoning. At the 6-week visit, if the child and parents agree, we will ask each child to provide a DNA sample by one of three methods: mouthwash, spit collection, or swabbing the inside of the child's cheek. Each child's DNA will be analyzed for genes that are known to affect outcome following brain injury.

Key facts

Study ID

NCT01059708

Run by

Intermountain Health Care, Inc.

People needed

40

Starts

2007-11-01

Expected to finish

2010-12-01

Last updated by the study team

2011-03-17

Who can join

Age: 6 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 6 through 16.
• Acute carbon monoxide poisoning. Since we will be identifying potentially eligible patients using an electronic tool, the diagnosis of CO poisoning should be established by the evaluating physician. However, with the initial contact with the patients' parents, we will confirm the diagnosis, and only those patients with CO poisoning will be eligible.
• Willing to come to Salt Lake City or Provo for evaluation

You may not qualify if…

• Prior history of neurological injury with permanent sequelae.
• Prior history of chronic neurological disorder such as attention deficit disorder, learning disability, multiple sclerosis, cerebral palsy, demyelinating disease, meningitis with sequelae
• Insulin dependent diabetes (due to the confound of possible brain microvascular disease and episodes of hypoglycemia)
• Use of illicit drugs
• Use of alcohol in excess
• Pregnancy
• Carbon monoxide poisoning from a suicide attempt or concomitant smoke inhalation
• Subject or parent/guardian non-English-speaking

Where it is running

• Intermountain Healthcare, LDS Hospital — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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