Cardiac MRI for Patients Enrolled in INFUSE-AMI

Completed

Conditions studied: Acute Myocardial Infarction, Coronary Artery Disease, Myocardial Fibrosis, Gadolinium, Myocardial Edema

In brief

Background: * INFUSE AMI is an ongoing clinical trial examining how patients with heart attacks are treated. The study's aim is to help determine the best way to treat patients with specific kinds of heart attacks caused by blood clots. * To evaluate the effect of the heart attack on the heart tissue and function, participants in the INFUSE-AMI study will have magnetic resonance imaging (MRI) scans of the heart at specific times after their heart attack. Objectives: \- To perform cardiac MRI scans on patients who are participating in the INFUSE-AMI study. Eligibility: \- Individuals at least 18 years of age who are enrolled in the INFUSE-AMI study. Design: * Participants will have an MRI scan of the heart about 5 days and between 23 and 44 days after their heart attack. The MRI scan at day 5 is optional. * Participants will provide a blood sample prior to the MRI scan. * During the scan, participants will be given a contrast drug to show the blood flow to and within the heart. An electrocardiogram will be used to monitor the heart during the procedure. * No other treatment will be provided in this protocol.

Key facts

Study ID

NCT01059214

Run by

National Heart, Lung, and Blood Institute (NHLBI)

People needed

455

Starts

2009-12-10

Expected to finish

2012-10-11

Last updated by the study team

2019-09-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• i. Known hypersensitivity or contraindication to gadolinium contrast
• ii. Severe kidney disease (eGFR <30 mLIminIl .73 m(2) BSA)
• iii. Pregnancy
• iv. Breast feeding (unless subject is willing to discard breast milk for 24 hours)
• v. Cardiac pacemaker or implantable defibrillator
• vi. Non-MRI compatible aneurysm clip
• vii. Neural stimulator (e.g. TENS unit)
• viii. Any implanted or magnetically activated device (e.g. insulin pump)
• ix. Any type of non-MRI compatible metallic ear implant
• x. Metal shavings in the orbits
• xi. Any metallic or foreign body, shrapnel, or bullet in a location which the physician feels would present a risk to the subject

Where it is running

• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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