Study of Treatments Used for White Spot Lesions After Orthodontic Treatment.

Completed · Not applicable

Conditions studied: Tooth Demineralization

In brief

The purpose of this study is to learn more about the management of white spot lesions that occur after orthodontic treatment. White spot lesions generally improve slightly with time. To date, there is no proven method to help white spot lesions improve faster. Two treatments, called MI Paste Plus and fluoride varnish, have shown some potential benefits in a laboratory setting but have not undergone testing in a clinical setting. Approximately 240 subjects are to be enrolled in this study. The study will take place in approximately 30 dental and orthodontic offices across Idaho, Montana, Oregon, Utah, and Washington as part of Northwest PRECEDENT, a five-state research network that was created to study the practical issues facing dentists/orthodontists and their patients, and to provide information that will improve the quality of oral health care as a whole. Researchers at the University of Washington and Oregon Health \& Science University share management and oversight of the network and research projects.

Key facts

Study ID

NCT01059058

Run by

University of Washington

People needed

240

Starts

2010-03-01

Expected to finish

2012-07-01

Last updated by the study team

2015-08-17

Who can join

Age: 12 and older, up to 20. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Completed fixed appliance orthodontic therapy within the past two years
• Have at least one white spot lesion on the facial surface of a maxillary central or lateral incisor tooth that was not present prior to treatment with fixed orthodontic appliances.
• Between the ages of 12 and 20 years of age
• Agrees to randomization to the different treatment protocols
• Signed informed consent obtained from a parent or guardian of the patient f the patient is under the age of eighteen

You may not qualify if…

• Not willing to be randomly assigned to one of the three treatment groups
• Any abnormal oral, medical, or mental conditions, including any milk-related allergies and/or any medical conditions involving the kidneys.
• Any patients who underwent therapy for white spot lesion after completion of orthodontic treatment
• Any white spot lesion present on qualifying teeth with frank cavitation
• Patient is non-English speaking or non-English reading

Where it is running

• University of Washington/NW PRECEDENT — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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